When to use que and when to use quién or cual are frequently asked questions.  As is what exactly is the difference ? 

QUE 

The translation for qué will be what, The translation for que will be that.

QUIÉN

The translation for quién/quiénes will be who or whom.

CUÁL

The translation for cuál/cuales will be which.

EL QUE

El que, la que, los que and las que can translate in English as that, who, whom or which.

EL CUAL

El cual, la cual, los cuales and las cuales can translate in English as that, who, whom or which.

LO QUE

Lo que is neuter and will translate in English as what or that which. This will be used more in written language than spoken.

LO CUAL

Lo cual is neuter and will translate in English as what or that which.  This will be used more in written language than spoken.